Originally from France, I obtained my Ph.D. at the Institute of Genetics & Development of Rennes-CNRS. My research was focused on understanding the in vitro molecular mechanisms involved in Duchene muscular dystrophy by investigating the influence of the lipid packing, membrane curvature and contraction/relaxation cycles on the interaction of Dystrophin with the sarcolemmal membrane.
Inspired by the membrane and its traffic, I joined Kirchhausen’s lab at Harvard Medical School and Boston Children’s Hospital at the end of 2013. I am working on two different exciting projects. The goal of the first project is to find a new tool to investigate in vitro weak lipid-protein interactions; specifically through a collaboration with MIT using biofunctionalized ferromagnetic beads that roll on a supported lipid bilayer. The second project aims to understand the precise mechanism of Intersectin during clathrin Clathrin-mediated endocytosis. In this stimulating work, I use CRISPR-Cas9 system for genome editing and cutting edge Lattice light sheet Microscopy for a precise 3D imaging.
During my free time, I enjoy cooking, wine tasting and traveling.
Moderna Therapeutics, Cambridge, MA