Monica Dayam, Ph.D.

Monica Dayam
Postdoctoral Fellow
Warren Alpert Building, Room 138
Roaya.Dayam [at]
Current Projects

I am trying to identify factors that mediate Antisense oligonucleotides (ASOs) uptake and the underlying mechanisms on how ASOs are released from the internalized compartments (i.e. endocytic compartments). To do that, I established a high-throughput CRISPR (clustered regularly interspaced short palindromic repeats) screen during which genes are disrupted on a whole-genomic scale in a reporter cell line, which expresses the reporter system and Cas9. The screen will help us  identify genes that are essential for ASO uptake and activity.

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