Highlights

Brain Expansion

New technique enables rapid, high resolution imaging of entire fruit fly brain and mouse neuronal circuits.

Ruixuan Gao, Shoh M. Asano, Srigokul Upadhyayula, Igor Pisarev, Daniel E. Milkie, Tsung-Li Liu, Ved Singh, Austin Graves, Grace H. Huynh, Yongxin Zhao, John Bogovic, Jennifer Colonell, Carolyn M. Ott, Christopher Zugates, Susan Tappan, Alfredo Rodriguez, Kishore R. Mosaliganti, Shu-Hsien Sheu, H. Amalia Pasolli, Song Pang, C. Shan Xu, Sean G. Megason, Harald Hess, Jennifer Lippincott Schwartz, Adam Hantman, Gerald M. Rubin, Tom Kirchhausen, Stephan Saalfeld, Yoshinori Aso, Edward S. Boyden, Eric Betzig.

Science  18 Jan 2019:
Vol. 363, Issue 6424, eaau8302
DOI: 10.1126/science.aau8302

Clathrin-mediated endocytosis in vivo.

Adapting a technique used by astronomers to study distant stars, researchers develop a microscope capable of capturing 3-D images and videos of cells inside living organisms in unprecedented detail.