A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms
Fu, T. M. Liu, G. Milkie, D. E. Ruan, X. Gorlitz, F. Shi, Y. Ferro, V. Divekar, N. S. Wang, W. York, H. M. Kilic, V. Mueller, M. Liang, Y. Daugird, T. A. Gacha-Garay, M. J. Larkin, K. A. Adikes, R. C. Harrison, N. Shirazinejad, C. Williams, S. Nourse, J. L. Sheu, S. H. Gao, L. Li, T. Mondal, C. Achour, K. Hercule, W. Stabley, D. R. Emmerich, K. Dong, P. Drubin, D. G. Liu, Z. J. Mumm, J. S. Koyama, M. Killilea, A. N. Bravo-Cordero, J. J. Keene, C. D. Luo, L. Kirchhausen, T. Pathak, M. M. Arumugam, S. Nunez, J. K. Gao, R. Matus, D. Q. Martin, B. L. Swinburne, I. A. Betzig, E. Legant, W. R. Upadhyayula, S.

Nat Methods, May 22, 2026

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Naked antisense oligonucleotides remain endolysosomally sequestered despite induced membrane damage
Sitarska, E. Saminathan, A. Scanavachi, G. Somerville, E. Courtney, M. F. Reid, D. A. Danielsen, M. B. Davidsen, F. K. N. Jensen, K. J. Bennett, C. F. Kirchhausen, T.

bioRxiv, May 13, 2026

How endosomal PIKfyve inhibition prevents viral membrane fusion and entry
Chow, N. Scanavachi, G. Saminathan, A. Kirchhausen, T.

Proc Natl Acad Sci, May 12, 2026

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Mechanism of membrane perforation in rotavirus cell entry
de Sautu, M. Leistner, C. Kirchhausen, T. Jenni, S. Harrison, S. C.

bioRxiv, Jan 31, 2026

SpatialDINO: A Self-Supervised 3D Vision Transformer that enables Segmentation and Tracking in Crowded Cellular Environments
Lavaee, A. Jain, A. Scanavachi, G. Costa-Filho, J. I. Ingemansson, A. Kirchhausen, T.

bioRxiv, Jan 25, 2026

Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM
Nair, A. Nair, A. Stock, P. Jain, A. Somerville, E. Sanyal, A. Costa-Filho, J. I. Kirchhausen, T.

J Cell Biol, Jan 5, 2026

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How endosomal PIKfyve inhibition prevents viral membrane fusion and entry
Chow, N. Scanavachi, G. Saminathan, A. Kirchhausen, T.

bioRxiv, Nov 26, 2025

Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomes
Sanyal, A. Scanavachi, G. Somerville, E. Aylan, B. Costa-Filho, J. I. Brooks, F. Dickson, J. R. Hyman, B. T. Kirchhausen, T.

bioRxiv, Nov 3, 2025

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms
Fu, T. M. Liu, G. Milkie, D. E. Ruan, X. Gorlitz, F. Shi, Y. Ferro, V. Divekar, N. S. Wang, W. York, H. M. Kilic, V. Mueller, M. Liang, Y. Daugird, T. A. Gacha-Garay, M. J. Larkin, K. A. Adikes, R. C. Harrison, N. Shirazinejad, C. Williams, S. Nourse, J. L. Sheu, S. H. Gao, L. Li, T. Mondal, C. Achour, K. Hercule, W. Stabley, D. Emmerich, K. Dong, P. Drubin, D. Liu, Z. J. Clapham, D. Mumm, J. S. Koyama, M. Killilea, A. Bravo-Cordero, J. J. Keene, C. D. Luo, L. Kirchhausen, T. Pathak, M. M. Arumugam, S. Nunez, J. K. Gao, R. Matus, D. Q. Martin, B. L. Swinburne, I. A. Betzig, E. Legant, W. R. Upadhyayula, S.

bioRxiv, June 3, 2025

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Deep learning-assisted analysis of single-particle tracking for automated correlation between diffusion and function
Kaestel-Hansen, J. de Sautu, M. Saminathan, A. Scanavachi, G. Bango Da Cunha Correia, R. F. Juma Nielsen, A. Bleshoy, S. V. Tsolakidis, K. Boomsma, W. Kirchhausen, T. Hatzakis, N. S.

Nature Methods, May 2025

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Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM
Athul Nair, Akhil Nair, Patrick Stock, Arkash Jain, Elliott Somerville, Anwesha Sanyal, Tom Kirchhausen.

bioRxix, April 24, 2025

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Neuronal constitutive endolysosomal perforations enable alpha-synuclein aggregation by internalized PFFs
Sanyal, A. Scanavachi, G. Somerville, E. Saminathan, A. Nair, A. Bango Da Cunha Correia, R. F. Aylan, B. Sitarska, E. Oikonomou, A. Hatzakis, N. S. Kirchhausen, T.

J Cell Biol, Feb 3, 2025

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CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data
Costa-Filho, J. I. Theveny, L. de Sautu, M. Kirchhausen, T.

J Struct Biol, Dec 20, 2024

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Pascolutti, R. Algisi, V. Conte, A. Raimondi, A. Pasham, M. Upadhyayula, S. Gaudin, R. Maritzen, T. Barbieri, E. Caldieri, G. Tordonato, C. Confalonieri, S. Freddi, S. Malabarba, M. G. Maspero, E. Polo, S. Tacchetti, C. Haucke, V. Kirchhausen, T. Di Fiore, P. P. Sigismund, S.

Cell Rep, Oct 30, 2024

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CryoSamba: self-supervised deep volumetric denoising for cryo-electron tomography data
Jose Inacio Costa-Filho, Liam Theveny, Marilina de Sautu, Tom Kirchhausen

bioRxiv, July 16, 2024

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Probing and imaging phospholipid dynamics in live cells
Zhongsheng Wu, Yongtao Du, Tom Kirchhausen, Kangmin He

Life Metabolism, Published: 13 April, 2024

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Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
Tveriakhina, L. Scanavachi, G. Egan, E. D. Da Cunha Correia, R. B. Martin, A. P. Rogers, J. M. Yodh, J. S. Aster, J. C. Kirchhausen, T. Blacklow, S. C.

Dev Cell, April 2024

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Deep learning assisted single particle tracking for automated correlation between diffusion and function
Nikos Hatzakis, Jacob Kaestel-Hansen, Marilina de Sautu, Anand Saminathan, Gustavo Scanavachi, Ricardo Correia, Annette Juma Nielsen, Sara Bleshoey, Wouter Boomsma, Tomas Kirchhausen

Res Sq [Preprint] Feb 2024

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Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils
Sanyal, A. Scanavachi, G. Somerville, E. Saminathan, A. Nair, A. Oikonomou, A. Hatzakis, N. S. Kirchhausen, T.

bioRxiv preprint, Jan 1, 2024

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Deep learning assisted single particle tracking for automated correlation between diffusion and function
Kaestel-Hansen, J. de Sautu, M. Saminathan, A. Scanavachi, G. Da Cunha Correia, R. F. B. Nielsen, A. J. Bleshoy, S. V. Boomsma, W. Kirchhausen, T. Hatzakis, N. S.

bioRxiv, Nov 17, 2023

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Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry
Lena Tveriakhina1,9, Gustavo Scanavachi2,3,9, Emily D. Egan1, Ricardo Bango Da Cunha Correia2,3, Alexandre P. Martin1, Julia M. Rogers1, Jeremy S. Yodh5, Jon C. Aster6, Tom Kirchhausen2,3,4*, Stephen C. Blacklow1,7,8,9,*

bioRxiv preprint, Sept 27, 2023

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A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility
Sheu, S. H. Upadhyayula, S. Dupuy, V. Pang, S. Deng, F. Wan, J. Walpita, D. Pasolli, H. A. Houser, J. Sanchez-Martinez, S. Brauchi, S. E. Banala, S. Freeman, M. Xu, C. S. Kirchhausen, T. Hess, H. F. Lavis, L. Li, Y. Chaumont-Dubel, S. Clapham, D. E.

Microsc Microanal, July 22, 2023

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A spatiotemporal Notch interaction map from plasma membrane to nucleus
Martin, A. P. Bradshaw, G. A. Eisert, R. J. Egan, E. D. Tveriakhina, L. Rogers, J. M. Dates, A. N. Scanavachi, G. Aster, J. C. Kirchhausen, T. Kalocsay, M. Blacklow, S. C.

Sci Signal, Aug 2023

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Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors
Kant, R. Kareinen, L. Ojha, R. Strandin, T. Saber, S. H. Lesnikova, A. Kuivanen, S. Sirnonen, T. Joensuu, M. Vapalahti, O. Kirchhausen, T. Kipar, A. Balistreri, G.

bioRxiv, July 20, 2023

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Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
Yang, K. Wang, C. Kreutzberger, A. J. B. White, K. I. Pfuetzner, R. A. Esquivies, L. Kirchhausen, T. Brunger, A. T.

Proc Natl Acad Sci U S A, Mar 28, 2023

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Deep neural network automated segmentation of cellular structures in volume electron microscopy
Gallusser, B. Maltese, G. Di Caprio, G. Vadakkan, T. J. Sanyal, A. Somerville, E. Sahasrabudhe, M. O'Connor, J. Weigert, M. Kirchhausen, T.

J Cell Biol, Feb 6, 2023

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The beauty of simplicity in membrane biology
Stachowiak, J. C. Kirchhausen, T.

Nat Cell Biol, Oct 20, 2022

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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
S. H. Sheu, S. Upadhyayula, V. Dupuy, S. Pang, F. Deng, J. Wan, et al.

Cell, Sept 1, 2022

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Deep neural network automated segmentation of cellular structures in volume electron microscopy
Benjamin Gallusser, Giorgio Maltese, Giuseppe Di Caprio, Tegy John Vadakkan, Anwesha Sanyal, Elliott Somerville, Mihir Sahasrabudhe, Justin O’Connor, ProfileMartin Weigert, Tom Kirchhausen

bioRxiv preprint: this version posted August 3, 2022

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tomas Kirchhausen, Axel T. Brunger

Proc Natl Acad Sci U S A, Oct 4, 2022

 

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An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion
Sai Luo, Jun Zhang, Alex J.B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D. Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S. Munir Alam, David C. Montefiori, Kevin O. Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F. Haynes, and Frederick W. Alt

Sci Immunol 2022 

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SARS-CoV-2 requires acidic pH to infect cells
Alex J.B. Kreutzberger, Anwesha Sanyal, Anand Saminathan, Louis-Marie Bloyet, Spencer Stumpf, Zhuoming Liu, Ravi Ojha, Markku T. Patjas, Ahmed Geneid, Gustavo Scanavachi, Catherine A. Doyle, Elliott Somerville, Ricardo Bango Da Cunha Correira, Giuseppe Di Caprio, Sanna Toppila-Salmi, Antti Mäkitie, Volker Kiessling, Olli Vapalahti, Sean P.J. Whelan, Giuseppe Balistreri, Tom Kirchhausen

Proc Natl Acad Sci U S A, 2022

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CD164 is a host factor for lymphocytic choriomeningitis virus entry
Bakkers, M. J. G. Moon-Walker, A. Herlo, R. Brusic, V. Stubbs, S. H. Hastie, K. M. Saphire, E. O. Kirchhausen, T. L. Whelan, S. P. J.

Proc Natl Acad Sci U S A, 2022

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Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease
Kreutzberger, A. J. B. Sanyal, A. Ojha, R. Pyle, J. D. Vapalahti, O. Balistreri, G. Kirchhausen, T.

J Virol, Oct 13, 2021

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Inherited nuclear pore substructures template postmitotic pore assembly
Chou, Y. Y. Upadhyayula, S. Houser, J. He, K. Skillern, W. Scanavachi, G. Dang, S. Sanyal, A. Ohashi, K. G. Di Caprio, G. Kreutzberger, A. J. B. Vadakkan, T. J. Kirchhausen, T.

Dev Cell, June 9, 2021

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Synergistic inhibition of two host factors that facilitate entry of Severe Acute Respiratory Syndrome Coronavirus 2
Kreutzberger, A. J. B. Sanyal, A. Ojha, R. Pyle, J. D. Vapalahti, O. Balistreri, G. Kirchhausen, T.

bioRxiv preprint June 9, 2021

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PKC-phosphorylation of Liprin-alpha3 triggers phase separation and controls presynaptic active zone structure
Emperador-Melero, J. Wong, M. Y. Wang, S. S. H. de Nola, G. Nyitrai, H. Kirchhausen, T. Kaeser, P. S.

Nat Commun, May 26, 2021

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Activating sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Chen, Y. C. Dinavahi, S. S. Feng, Q. Gowda, R. Ramisetti, S. Xia, X. LaPenna, K. B. Chirasani, V. R. Cho, S. H. Hafenstein, S. L. Battu, M. B. Berg, A. Sharma, A. K. Kirchhausen, T. Dokholyan, N. V. Amin, S. He, P. Robertson, G. P.

Cancer Lett 2021

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Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging
Salman, M. M. Marsh, G. Kusters, I. Delince, M. Di Caprio, G. Upadhyayula, S. de Nola, G. Hunt, R. Ohashi, K. G. Gray, T. Shimizu, F. Sano, Y. Kanda, T. Obermeier, B. Kirchhausen, T.

Front Bioeng Biotechnol, Oct 30, 2020

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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Ruochen Zang, James Brett Case, Maria Florencia Gomez Castro, Zhuoming Liu, Qiru Zeng, Haiyan Zhao, Juhee Son, Paul W. Rothlauf, Gaopeng Hou, Sayantan Bose, Xin Wang, Michael D. Vahey, Tomas Kirchhausen, Daved H. Fremont, Michael S. Diamond, Sean P.J. Whelan, Siyuan.Ding

bioRxiv preprint, June 9, 2020

Proc Natl Acad Sci U S A Nov 27, 2020

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An in-vitro BBB-on-a-chip open model of human blood-brain barrier enabling advanced optical imaging
Mootaz Salman, Graham Marsh, Ilja Küsters, Matthieu Delincé, Giuseppe Di Caprio, Srigokul Upadhyayula, Giovanni de Nola, Ronan Hunt, Kazuka G. Ohashi, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Birgit Obermeier, Tom Kirchhausen

bioRxiv preprint, July 1, 2020

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Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface
Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., Kishkovich, T., Jang, E., Klein, E. M., Goldey, G. J., He, K., Zhang, Y., Holtzman, M. J., Kirchhausen, T., Wyart, C., Moore, C. I., Andermann, M. L., Lehtinen, M. K.

Neuron, 2020 Sep 15 

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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Venkat Giri Magupalli # 1 2 , Roberto Negro # 1 2 , Yuzi Tian # 3 4 , Arthur V Hauenstein # 5 2 , Giuseppe Di Caprio 2 6 , Wesley Skillern 2 , Qiufang Deng 3 4 , Pontus Orning 7 8 , Hasan B Alam 3 , Zoltan Maliga 9 , Humayun Sharif 5 2 , Jun Jacob Hu 5 2 , Charles L Evavold 10 , Jonathan C Kagan 10 , Florian I Schmidt 11 , Katherine A Fitzgerald 7 8 , Tom Kirchhausen 2 6 , Yongqing Li 12 , Hao Wu 1

Science 2020 Sep 18;369

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Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Kang, Y. L. Chou, Y. Y. Rothlauf, P. W. Liu, Z. Soh, T. K. Cureton, D. Case, J. B. Chen, R. E. Diamond, M. S. Whelan, S. P. J. Kirchhausen, T.

Proc Natl Acad Sci U S A 2020 Aug 25;117(34):20803-20813

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Oligomerization of the vesicular stomatitis virus phosphoprotein is dispensable
Louis-Marie Bloyet1§, Benjamin Morin1§*, Vesna Brusic1, Erica Gardner1, Robin A. Ross1, Tegy Vadakkan2, Tomas Kirchhausen2 and Sean P. J. Whelan1,3#.

JVI, Posted Online 22 April 2020

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Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2
Yuan-Lin Kang1,2,3, Yi-Ying Chou1,2,4, Paul W. Rothlauf5,6, Zhuoming Liu5, Silvia Piccinotti6, Timothy K. Soh6, David Cureton6,7, James Brett Case8, Rita E. Chen5,8, Michael S. Diamond5,8, Sean P. J. Whelan5,*, Tom Kirchhausen1,2,9,*

bioRxiv Apr 21;2020.

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Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells
Hoffman, D. P. Shtengel, G. Xu, C. S. Campbell, K. R. Freeman, M. Wang, L. Milkie, D. E. Pasolli, H. A. Iyer, N. Bogovic, J. A. Stabley, D. R. Shirinifard, A. Pang, S. Peale, D. Schaefer, K. Pomp, W. Chang, C. L. Lippincott-Schwartz, J. Kirchhausen, T. Solecki, D. J. Betzig, E. Hess, H. F.

Science 2020 Jan 17;367(6475)

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Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic
He, K. Song, E. Upadhyayula, S. Dang, S. Gaudin, R. Skillern, W. Bu, K. Capraro, B. R. Rapoport, I. Kusters, I. Ma, M. Kirchhausen, T.

J Cell Biol 2020 Mar 2;219(3)

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Pascolutti, R. Algisi, V. Conte, A. Raimondi, A. Pasham, M. Upadhyayula, S. Gaudin, R. Maritzen, T. Barbieri, E. Caldieri, G. Tordonato, C. Confalonieri, S. Freddi, S. Malabarba, M. G. Maspero, E. Polo, S. Tacchetti, C. Haucke, V. Kirchhausen, T. Di Fiore, P. P. Sigismund, S.

Cell Rep 2019 Jun 4;27(10):3049-3061

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F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects
Calzoni, E. Platt, C. D. Keles, S. Kuehn, H. S. Beaussant-Cohen, S. Zhang, Y. Pazmandi, J. Lanzi, G. Pala, F. Tahiat, A. Artac, H. Heredia, R. J. Dmytrus, J. Reisli, I. Uygun, V. Uygun, D. Bingol, A. Basaran, E. Djenouhat, K. Benhalla, N. Bendahmane, C. Emiroglu, M. Kirchhausen, T. Pasham, M. Jones, J. Wallace, J. G. Zheng, L. Boisson, B. Porta, F. Rosenzweig, S. D. Su, H. Giliani, S. Lenardo, M. Geha, R. S. Boztug, K. Chou, J. Notarangelo, L. D.

J Allergy Clin Immunol 2019 Jun;143(6):2317-2321

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Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution
Gao, R., Asano, S. M., Upadhyayula, S., Pisarev, I., Milkie, D. E., Liu, T.-L., Singh, V., Graves, A., Huynh, G. H., Zhao, Y., Bogovic, J., Colonell, J., Ott, C. M., Zugates, C., Tappan, S., Rodriguez, A., Mosaliganti, K. R., Megason, S. G., Lippincott-Schwartz, J., Hantman, A., Rubin, G. M., Kirchhausen, T., Saalfeld, S., Aso, Y., Boyden, E. S. & Betzig, E.

Science 2019 Jan 18;363(6424)

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Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis
Bocking, T. Upadhyayula, S. Rapoport, I. Capraro, B. R. Kirchhausen, T.

Methods Mol Biol. 2018;1847:121-146

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The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles
Coulter, M. E. Dorobantu, C. M. Lodewijk, G. A. Delalande, F. Cianferani, S. Ganesh, V. S. Smith, R. S. Lim, E. T. Xu, C. S. Pang, S. Wong, E. T. Lidov, H. G. W. Calicchio, M. L. Yang, E. Gonzalez, D. M. Schlaeger, T. M. Mochida, G. H. Hess, H. Lee, W. A. Lehtinen, M. K. Kirchhausen, T. Haussler, D. Jacobs, F. M. J. Gaudin, R. Walsh, C. A.

Cell Rep 2018 Jul 24;24(4):973-986.e8

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Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure
Swinburne, I. A. Mosaliganti, K. R. Upadhyayula, S. Liu, T. L. Hildebrand, D. G. C. Tsai, T. Y. Chen, A. Al-Obeidi, E. Fass, A. K. Malhotra, S. Engert, F. Lichtman, J. W. Kirchausen, T. Betzig, E. Megason, S. G.

Elife 2018 Jun 19;7:e37131

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Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
Liu, T. L. Upadhyayula, S. Milkie, D. E. Singh, V. Wang, K. Swinburne, I. A. Mosaliganti, K. R. Collins, Z. M. Hiscock, T. W. Shea, J. Kohrman, A. Q. Medwig, T. N. Dambournet, D. Forster, R. Cunniff, B. Ruan, Y. Yashiro, H. Scholpp, S. Meyerowitz, E. M. Hockemeyer, D. Drubin, D. G. Martin, B. L. Matus, D. Q. Koyama, M. Megason, S. G. Kirchhausen, T. Betzig, E.

Science 2018 Apr 20;360(6386):eaaq1392

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Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms
Liu, T. L. Upadhyayula, S. Milkie, D. E. Singh, V. Wang, K. Swinburne, I. A. Mosaliganti, K. R. Collins, Z. M. Hiscock, T. W. Shea, J. Kohrman, A. Q. Medwig, T. N. Dambournet, D. Forster, R. Cunniff, B. Ruan, Y. Yashiro, H. Scholpp, S. Meyerowitz, E. M. Hockemeyer, D. Drubin, D. G. Martin, B. L. Matus, D. Q. Koyama, M. Megason, S. G. Kirchhausen, T. Betzig, E.

bioRvix 2018 

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Lamellar Junctions In The Endolymphatic Sac Act As A Relief Valve To Regulate Inner Ear Pressure
Swinburne, I. A. Mosaliganti, K. R. Upadhyayula, S. Liu, T. L. Hildebrand, D. G. C. Tsai, T. Y. Chen, A. Al-Obeidi, E. Fass, A. K. Malhotra, S. Engert, F. Lichtman, J. W. Kirchausen, T. Betzig, E. Megason, S. G.

bioRvix 2017

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Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic
He, K. Marsland Iii, R. Upadhyayula, S. Song, E. Dang, S. Capraro, B. R. Wang, W. Skillern, W. Gaudin, R. Ma, M. Kirchhausen, T.

Nature 2017 Dec 21;552(7685):410-414

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Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing
Bruna S. Paulsen, Pankaj K. Mandal, Richard L. Frock, Baris Boyraz, Rachita Yadav, Srigokul Upadhyayula, Paula Gutierrez-Martinez, Wataru Ebina, Anders Fasth, Tomas Kirchhausen, Michael E. Talkowski, Suneet Agarwal, Frederick W. Alt & Derrick J. Rossi

Nat Biomed Eng 2017 Nov;1(11):878-888

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NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry
Raaben, M. Jae, L. T. Herbert, A. S. Kuehne, A. I. Stubbs, S. H. Chou, Y. Y. Blomen, V. A. Kirchhausen, T. Dye, J. M. Brummelkamp, T. R. Whelan, S. P.

Cell Host Microbe 2017 Nov 8;22(5):688-696.e5

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Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding
Adell, M. A. Y. Migliano, S. M. Upadhyayula, S. Bykov, Y. S. Sprenger, S. Pakdel, M. Vogel, G. F. Jih, G. Skillern, W. Behrouzi, R. Babst, M. Schmidt, O. Hess, M. W. Briggs, J. A. Kirchhausen, T. Teis, D.

Elife, Volume 6, Oct 11

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Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration
Schuler, M. H. Lewandowska, A. Di Caprio, G. Skillern, W. Upadhyayula, S. Kirchhausen, T. Shaw, J. M. Cunniff, B.

Mol Biol Cell (2017)

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Seipin is required for converting nascent to mature lipid droplets
Wang, H Becuwe, M Housden, B. E Chitraju, C Porras, A. J Graham, M. M Liu, X. N Thiam, A. R Savage, D. B Agarwal, A. K Garg, A Olarte, M. J Lin, Q Frohlich, F Hannibal-Bach, H. K Upadhyayula, S Perrimon, N Kirchhausen, T Ejsing, C. S Walther, T. C Farese, R. V.

eLife (2016), Volume: 5

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Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion
Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T,

The Journal of experimental medicine (2016)

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Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9
Yi-Ying Chou, Annabel Krupp, Campbell Kaynor, Raphaël Gaudin, Minghe Ma, Ellen Cahir-McFarland, Tom Kirchhausen

Sci Rep (2016)

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Membrane fission by dynamin: what we know and what we need to know
Antonny, B Burd, C De Camilli, P Chen, E Daumke, O Faelber, K Ford, M Frolov, V. A Frost, A Hinshaw, J. E Kirchhausen, T Kozlov, M. M Lenz, M Low, H. H McMahon, H Merrifield, C Pollard, T. D Robinson, P. J Roux, A Schmid, S.

The EMBO journal (2016)

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Identification and characterization of a novel broad spectrum virus entry inhibitor
Chou, Y. Y Cuevas, C Carocci, M Stubbs, S. H Ma, M Cureton, D. K Chao, L Evesson, F He, K Yang, P. L Whelan, S. P Ross, S. R Kirchhausen, T Gaudin, R.

Journal of virology (2016)

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Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
Aguet, F Upadhyayula, S Gaudin, R Chou, Y. Y Cocucci, E He, K Chen, B. C Mosaliganti, K Pasham, M Skillern, W Legant, W. R Liu, T. L Findlay, G Marino, E Danuser, G Megason, S Betzig, E Kirchhausen, T.

Molecular biology of the cell (2016)

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Data publication with the structural biology data grid supports live analysis
Meyer, P. A Socias, S Key, J Ransey, E Tjon, E. C Buschiazzo, A Lei, M Botka, C Withrow, J Neau, D Rajashankar, K Anderson, K. S Baxter, R. H Blacklow, S. C Boggon, T. J Bonvin, A. M Borek, D Brett, T. J Caflisch, A Chang, C. I Chazin, W. J Corbett, K. D Cosgrove, M. S Crosson, S Dhe-Paganon, S Di Cera, E Drennan, C. L Eck, M. J Eichman, B. F Fan, Q. R Ferre-D'Amare, A. R Christopher Fromme, J Garcia, K. C Gaudet, R Gong, P Harrison, S. C Heldwein, E. E Jia, Z Keenan, R. J Kruse, A. C Kvansakul, M McLellan, J. S Modis, Y Nam, Y Otwinowski, Z Pai, E. F Pereira, P. J Petosa, C Raman, C. S Rapoport, T. A Roll-Mecak, A Rosen, M. K Rudenko, G Schlessinger, J Schwartz, T. U Shamoo, Y Sondermann, H Tao, Y. J Tolia, N. H Tsodikov, O. V Westover, K. D Wu, H Foster, I Fraser, J. S Maia, F. R Gonen, T Kirchhausen, T Diederichs, K Crosas, M Sliz, P.

Nature communications (2016), Volume: 7, Pages: 10882

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ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics
Li, D Shao, L Chen, B. C Zhang, X Zhang, M Moses, B Milkie, D. E Beach, J. R Hammer, J. A., 3rdPasham, M Kirchhausen, T Baird, M. A Davidson, M. W Xu, P Betzig, E.

Science (2015), Volume: 349, Issue: 6251, Pages: aab3500

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Cell imaging: Beyond the limits
Bourzac, K.

Nature (2015), Volume: 526, Issue: 7574, Pages: S50-4

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Endocytosis of ligand activated sphingosine 1-phosphate receptor 1 mediated by the clathrin-pathway
Reeves, P. M Kang, Y. L Kirchhausen, T.

Traffic (2015)

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Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells
Gaudin, R Kirchhausen, T.

Scientific reports (2015), Volume: 5, Pages: 15990

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Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edge of motile cells and on protrusions of immobile cells
Kural, C Akatay, A. A Gaudin, R Chen, B. C Legant, W. R Betzig, E Kirchhausen, T.

Molecular biology of the cell (2015)

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Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
Wittrup, A Ai, A Liu, X Hamar, P Trifonova, R Charisse, K Manoharan, M Kirchhausen, T Lieberman, J.

Nature biotechnology (2015), Volume: 33, Issue: 8, Pages: 870-6

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Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology
Ishikawa, Y Maeda, M Pasham, M Aguet, F Tacheva-Grigorova, S. K Masuda, T Yi, H Lee, S Xu, J Teruya-Feldstein, J Ericsson, M Mullally, A Heuser, J Kirchhausen, T Maeda, T.

Haematologica (2014)

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Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit
Cocucci, E Gaudin, R Kirchhausen, T.

Molecular biology of the cell (2014)

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In-vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos
Hagemann, A. I Kurz, J Kauffeld, S Chen, Q Reeves, P. M Weber, S Schindler, S Davidson, G Kirchhausen, T Scholpp, S.

Journal of cell science (2014)

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Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes
Walch, M Dotiwala, F Mulik, S Thiery, J Kirchhausen, T Clayberger, C Krensky, A. M Martinvalet, D Lieberman, J.

Cell (2014), Volume: 157, Issue: 6, Pages: 1309-1323

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Key Interactions for Clathrin Coat Stability
Bocking, T Aguet, F Rapoport, I Banzhaf, M Yu, A Zeeh, J. C Kirchhausen, T.

Structure (2014)

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The timing of pre-mRNA splicing visualized in real-time.
Carmo-Fonseca, M Kirchhausen, T.

Nucleus (2014), Volume: 5, Issue: 1

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Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic
Kirchhausen, T Owen, D Harrison, S. C.

Cold Spring Harbor perspectives in biology (2014), Volume: 6, Issue: 5

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Structural correlates of rotavirus cell entry
Abdelhakim, A. H Salgado, E. N Fu, X Pasham, M Nicastro, D Kirchhausen, T Harrison, S. C.

PLoS pathogens (2014), Volume: 10, Issue: 9, Pages: e1004355

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Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity
Martin, R. M Rino, J Carvalho, C Kirchhausen, T Carmo-Fonseca, M.

Cell Reports (2013)

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Similar uptake but different trafficking and escape routes of reovirus virions and ISVPs imaged in polarized MDCK cells
Boulant, S Stanifer, M Kural, C Cureton, D. K Massol, R Nibert, M. L Kirchhausen, T.

Molecular biology of the cell (2013)

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Clathrin-Mediated Endocytosis Persists during Unperturbed Mitosis
Tacheva-Grigorova, S. K Santos, A. J Boucrot, E Kirchhausen, T.

Cell Reports (2013), Volume: 4, Issue: 4, Pages: 659-68

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Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin
Piccinotti, S Kirchhausen, T Whelan, S. P.

Journal of Virology (2013)

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Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds
Martinelli, R Kamei, M Sage, P. T Massol, R Varghese, L Sciuto, T Toporsian, M Dvorak, A. M Kirchhausen, T Springer, T. A Carman, C. V.

The Journal of cell biology (2013), Volume: 201, Issue: 3, Pages: 449-65

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Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation
Heesters, B. A Chatterjee, P Kim, Y. A Gonzalez, S. F Kuligowski, M. P Kirchhausen, T Carroll, M. C.

Immunity (2013), Volume: 38, Issue: 6, Pages: 1164-75

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The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export
Lu, L Hannoush, R. N Goess, B. C Varadarajan, S Shair, M. D Kirchhausen, T.

Molecular biology of the cell (2013)

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Bending Membranes
Tom Kirchhausen

Nat Cell Biol (2012), Volume: 14, Issue: 9, Pages: 906-8

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Small Molecule-Mediated TGF-beta Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells
Willems, E Cabral-Teixeira, J Schade, D Cai, W Reeves, P Bushway, P. J Lanier, M Walsh, C Kirchhausen, T Izpisua Belmonte, J. C Cashman, J Mercola, M.

Cell Stem Cell (2012), Volume: 11, Issue: 2, Pages: 242-52

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The first five seconds in the life of a clathrin-coated pit
Cocucci, E Aguet, F Boulant, S Kirchhausen, T.

Cell (2012), Volume: 150, Issue: 3, Pages: 495-507

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Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers
Kural, C Tacheva-Grigorova, S. K Boulant, S Cocucci, E Baust, T Duarte, D Kirchhausen, T.

Cell Rep (2012)

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Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane
Lu, L Kirchhausen, T.

Commun Integr Biol (2012), Volume: 5, Issue: 1, Pages: 16-18

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Regulation of ligand-independent Notch signal through intracellular trafficking
Hori, K Sen, A Kirchhausen, T Artavanis-Tsakonas, S.

Commun Integr Biol (2012), Volume: 5, Issue: 4, Pages: 374-6

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Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments
Strang, B. L Boulant, S Kirchhausen, T Coen, D. M.

MBio (2012), Volume: 3, Issue: 1

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Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures
Cureton, D. K Harbison, C. E Cocucci, E Parrish, C. R Kirchhausen, T.

J Virol (2012)

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Live-cell imaging of clathrin coats
Kural, C Kirchhausen, T.

Methods Enzymol (2012), Volume: 505, Pages: 59-80

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Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly
Lu, L Ladinsky, M. S Kirchhausen, T.

J Cell Biol (2011), Volume: 194, Issue: 3, Pages: 425-40

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Recruitment of Cellular Clathrin to Viral Factories and Disruption of Clathrin-Dependent Trafficking
Ivanovic, T Boulant, S Ehrlich, M Demidenko, A. A Arnold, M. M Kirchhausen, T Nibert, M. L.

Traffic (2011)

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Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating
Bocking, T Aguet, F Harrison, S. C Kirchhausen, T.

Nat Struct Mol Biol (2011), Volume: 18, Issue: 3, Pages: 295-301

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Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
Boulant, S Kural, C Zeeh, J. C Ubelmann, F Kirchhausen, T.

Nat Cell Biol (2011), Volume: 13, Issue: 9, Pages: 1124-31

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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells
Thiery, J Keefe, D Boulant, S Boucrot, E Walch, M Martinvalet, D Goping, I. S Bleackley, R. C Kirchhausen, T Lieberman, J.

Nat Immunol (2011)

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ARFGAP1 promotes AP-2-dependent endocytosis
Bai, M Gad, H Turacchio, G Cocucci, E Yang, J. S Li, J Beznoussenko, G. V Nie, Z Luo, R Fu, L Collawn, J. F Kirchhausen, T Luini, A Hsu, V. W.

Nat Cell Biol (2011), Volume: 13, Issue: 5, Pages: 559-67

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Redistribution of caveolae during mitosis
Boucrot, E Howes, M. T Kirchhausen, T Parton, R. G.

J Cell Sci (2011), Volume: 124, Issue: Pt 12, Pages: 1965-72

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Human Cytomegalovirus UL44 Concentrates at the Periphery of Replication Compartments, the Site of Viral DNA Synthesis
Strang, B. L Boulant, S Chang, L Knipe, D. M Kirchhausen, T Coen, D. M.

J Virol (2011)

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Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
Hori, K Sen, A Kirchhausen, T Artavanis-Tsakonas, S.

J Cell Biol (2011), Volume: 195, Issue: 6, Pages: 1005-15

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The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis
Cureton, D. K., Massol, R. H., Whelan, S. P. and Kirchhausen, T.

PLoS Pathogens (2010), Volume: 6, Issue: 9

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Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.
Yu, A., Xing, Y., Harrison, S. C. and Kirchhausen, T.

Structure (2010), Volume: 18, Issue: 10, Pages: 1311-20

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Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding
Guan, R., Han, D., Harrison, S. C., Kirchhausen, T.

Structure (2010), Volume: 18, Issue: 9, Pages: 1191-8

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Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase
Audrun Utskarpen, Ramiro Massol, Bo van Deurs, Silje Ugland Lauvrak, Tomas Kirchhausen, Kirsten Sandvig

PloS One (2010), Volume: 5, Issue: 7, Pages: e10944

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Structural biology: Conservation in vesicle coats
Harrison, S.C., Kirchhausen, T.

Nature (2010), Volume: 466, Issue: 7310, Pages: 1048-9

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Roles of AP-2 in clathrin-mediated endocytosis
Boucrot, E., Saffarian, S., Zhang, R., Kirchhausen, T.

PloS One (2010), Volume: 5, Issue: 5, Pages: e110597

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Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
Anitei, M., Stange, C., Parshina, I., Baust, T., Schenck, A., Raposo, G., Kirchhausen, T., Hoflack, B.

Nat Cell Biol (2010), Volume: 12, Issue: 4, Pages: 330-40

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Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly
Yi Xing, Till Böcking, Matthias Wolf, Nikolaus Grigorieff, Tomas Kirchhausen and Stephen C. Harrison

Embo (2010), Volume: 29, Issue: 3, Pages: 655-65

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Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210
Smits, P., et al.

N Engl J Med (2010), Volume: 362, Issue: 3, Pages: 206-16

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Perforin activates clathrin and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis
Jerome Thiery, Dennis Keefe, Saviz Saffarian, Denis Martinvalet, Michael Walch, Emmanuel Boucrot, Tomas Kirchhausen and Judy Lieberman

Blood (2009)

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Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization
Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP

PLoS pathogens (2009), Volume: 5, Issue: 4, Pages: e1000394

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Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin
Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O et al

Immunity (2009), Volume: 30, Issue: 3, Pages: 384-396

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Imaging endocytic clathrin structures in living cells
T. Kirchhausen

Trends Cell Biol (2009), Volume: 19, Issue: 11, Pages: 596-605

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Cisternal organization of the endoplasmic reticulum during mitosis
Lu L, Ladinsky MS, Kirchhausen T

Molecular biology of the cell (2009), Volume: 20, Issue: 15, Pages: 3471-80

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Distinct Dynamics of Endocytic Clathrin-Coated Pits and Coated Plaques
Saveez Saffarian, Emanuele Cocucci, Tomas Kirchhausen

PloS Biol (2009), Volume: 7, Issue: 9, Pages: e1000191

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Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane
Saffarian, S.; Kirchhausen, T.

Biophys J (2008), Volume: 94, Issue: 6, Pages: 2333-42

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Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
Nieland, T. J.; Shaw, J. T.; Jaipuri, F. A.; Duffner, J. L.; Koehler, A. N.; Banakos, S.; Zannis, V. I.; Kirchhausen, T.; Krieger, M.

Biochemistry (2008), Volume: 47, Issue: 1, Pages: 460-72

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Mammalian cells change volume during mitosis
Boucrot, E.; Kirchhausen, T.

PloS ONE (2008), Volume: 3, Issue: 1, Pages: e1477

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The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
Ambrogio, C.; Voena, C.; Manazza, A. D.; Martinengo, C.; Costa, C.; Kirchhausen, T.; Hirsch, E.; Inghirami, G.; Chiarle, R.

Cancer Res (2008), Volume: 68, Issue: 21, Pages: 8899-907

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Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis
Kirchhausen, T.; Macia, E.; Pelish, H. E.

Meth Enzymol (2008), Volume: 438, Pages: 77-93

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A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction
Rapoport, I.; Boll, W.; Yu, A.; Bocking, T.; Kirchhausen, T.

Mol Biol Cell (2008), Volume: 19, Issue: 1, Pages: 405-13

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Endosomal recycling controls plasma membrane area during mitosis
Boucrot, E.; Kirchhausen, T.

Proc Natl Acad Sci (2007), Volume: 104, Issue: 19, Pages: 7939-44

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Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling
Yu, A.; Rual, J. F.; Tamai, K.; Harada, Y.; Vidal, M.; He, X.; Kirchhausen, T.

Dev Cell (2007), Volume: 12, Issue: 1, Pages: 129-41

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An ACAP1-containing clathrin coat complex for endocytic recycling
Li, J.; Peters, P. J.; Bai, M.; Dai, J.; Bos, E.; Kirchhausen, T.; Kandror, K. V.; Hsu, V. W.

J Cell Biol (2007), Volume: 178, Issue: 3, Pages: 453-64

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Making COPII coats
Kirchhausen, T.

Cell (2007), Volume: 129, Issue: 7, Pages: 1251-2

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Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation
Ma, Y. M.; Boucrot, E.; Villen, J.; Affar el, B.; Gygi, S. P.; Gottlinger, H. G.; Kirchhausen, T.

J Biol Chem (2007), Volume: 282, Issue: 13, Pages: 9805-12

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PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiq
Wang, J.; Sun, H. Q.; Macia, E.; Kirchhausen, T.; Watson, H.; Bonifacino, J. S.; Yin, H. L.

Mol Biol Cell (2007), Volume: 18, Issue: 7, Pages: 2646-55

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Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly
Cheng, Y.; Boll, W.; Kirchhausen, T.; Harrison, S. C.; Walz, T.

J Mol Biol (2007), Volume: 365, Issue: 3, Pages: 892-9

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Invasive and adherent bacterial pathogens co-Opt host clathrin for infection
Veiga, E.; Guttman, J. A.; Bonazzi, M.; Boucrot, E.; Toledo-Arana, A.; Lin, A. E.; Enninga, J.; Pizarro-Cerda, J.; Finlay, B. B.; Kirchhausen, T.; Cossart, P.

Cell Host Microbe (2007), Volume: 2, Issue: 5, Pages: 340-51

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Tracking molecular particles in live cells using fuzzy rule-based system
Jiang, S.; Zhou, X.; Kirchhausen, T.; Wong, S. T.

(2007), Volume: 71, Issue: 8, Pages: 576-84

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Detection of molecular particles in live cells via machine learning
Jiang, S.; Zhou, X.; Kirchhausen, T.; Wong, S. T.

Cytometry (2007), Volume: 71, Issue: 8, Pages: 563-75

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Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
Pelish, H. E.; Peterson, J. R.; Salvarezza, S. B.; Rodriguez-Boulan, E.; Chen, J. L.; Stamnes, M.; Macia, E.; Feng, Y.; Shair, M. D.; Kirchhausen, T.

Nat Chem Biol (2006), Volume: 2, Issue: 1, Pages: 39-46

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The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells
Pelish, H. E.; Ciesla, W.; Tanaka, N.; Reddy, K.; Shair, M. D.; Kirchhausen, T.; Lencer, W. I.

Biochem Pharmacol (2006), Volume: 71, Issue: 12, Pages: 1720-6

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Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading
Xu, B.; Pelish, H.; Kirchhausen, T.; Hammond, G. B.

Org Biomol (2006), Volume: 4, Issue: 22, Pages: 4149-57

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Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors
Goess, B. C.; Hannoush, R. N.; Chan, L. K.; Kirchhausen, T.; Shair, M. D.

J Am Chem (2006), Volume: 128, Issue: 16, Pages: 5391-403

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Role of lipids and actin in the formation of clathrin-coated pits
Boucrot, E.; Saffarian, S.; Massol, R.; Kirchhausen, T.; Ehrlich, M.

Exp Cell (2006), Volume: 312, Issue: 20, Pages: 4036-48

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Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis
Newton, A. J.; Kirchhausen, T.; Murthy, V. N.

Proc Natl Acad Sci (2006), Volume: 103, Issue: 47, Pages: 17955-60

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Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events
Falcone, S.; Cocucci, E.; Podini, P.; Kirchhausen, T.; Clementi, E.; Meldolesi, J.

J Cell Sci (2006), Volume: 119, Issue: Pt 22, Pages: 4758-69

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Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy
Fotin, A.; Kirchhausen, T.; Grigorieff, N.; Harrison, S. C.; Walz, T.; Cheng, Y.

J Struct Biol (2006), Volume: 156, Issue: 3, Pages: 453-60

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Dynasore, a cell-permeable inhibitor of dynamin
Macia, E.; Ehrlich, M.; Massol, R.; Boucrot, E.; Brunner, C.; Kirchhausen, T.

Dev Cell (2006), Volume: 10, Issue: 6, Pages: 839-50

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A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating
Massol, R. H.; Boll, W.; Griffin, A. M.; Kirchhausen, T.

Proc Natl Acad Sci (2006), Volume: 103, Issue: 27, Pages: 10265-70

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Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis
Keefe, D.; Shi, L.; Feske, S.; Massol, R.; Navarro, F.; Kirchhausen, T.; Lieberman, J.

Immunity (2005), Volume: 23, Issue: 3, Pages: 249-62

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An emergency response team for membrane repair
McNeil, P. L.; Kirchhausen, T.

Nat Rev Mol Cell Biol (2005), Volume: 6, Issue: 6, Pages: 499-505

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Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI
Nieland, T. J.; Ehrlich, M.; Krieger, M.; Kirchhausen, T.

Biochim Biophys Acta (2005), Volume: 1734, Issue: 1, Pages: 44-51

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Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking
Massol, R. H.; Larsen, J. E.; Kirchhausen, T.

Exp Cell Res (2005), Volume: 306, Issue: 1, Pages: 142-9

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The transcription factor NFAT3 mediates neuronal survival
Benedito, A. B.; Lehtinen, M.; Massol, R.; Lopes, U. G.; Kirchhausen, T.; Rao, A.; Bonni, A.

J Biol Chem (2005), Volume: 280, Issue: 4, Pages: 2818-25

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Single-molecule live-cell imaging of clathrin-based endocytosis
Kirchhausen, T.; Boll, W.; van Oijen, A.; Ehrlich, M.

Biochem Soc Symp (2005), Issue: 72, Pages: 71-6

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The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes
Paleotti, O.; Macia, E.; Luton, F.; Klein, S.; Partisani, M.; Chardin, P.; Kirchhausen, T.; Franco, M.

J Biol Chem (2005), Volume: 280, Issue: 22, Pages: 21661-6

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Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Fotin, A.; Cheng, Y.; Grigorieff, N.; Walz, T.; Harrison, S. C.; Kirchhausen, T.

Nature (2004), Volume: 432, Issue: 7017, Pages: 649-53

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Crystal structure of the clathrin adaptor protein 1 core
Heldwein, E. E.; Macia, E.; Wang, J.; Yin, H. L.; Kirchhausen, T.; Harrison, S. C.

Proc Natl Acad Sci (2004), Volume: 101, Issue: 39, Pages: 14108-13

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Endocytosis by random initiation and stabilization of clathrin-coated pits
Ehrlich, M.; Boll, W.; Van Oijen, A.; Hariharan, R.; Chandran, K.; Nibert, M. L.; Kirchhausen, T.

Cell (2004), Volume: 118, Issue: 5, Pages: 591-605

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Molecular model for a complete clathrin lattice from electron cryomicroscopy
Fotin, A.; Cheng, Y.; Sliz, P.; Grigorieff, N.; Harrison, S. C.; Kirchhausen, T.; Walz, T.

Nature (2004), Volume: 432, Issue: 7017, Pages: 573-9

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Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells
Feng, Y.; Jadhav, A. P.; Rodighiero, C.; Fujinaga, Y.; Kirchhausen, T.; Lencer, W. I.

EMBO Rep (2004), Volume: 5, Issue: 6, Pages: 596-601

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Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide
Nieland, T. J.; Chroni, A.; Fitzgerald, M. L.; Maliga, Z.; Zannis, V. I.; Kirchhausen, T.; Krieger, M.

J Lipid Res (2004), Volume: 45, Issue: 7, Pages: 1256-65

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Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways
Massol, R. H.; Larsen, J. E.; Fujinaga, Y.; Lencer, W. I.; Kirchhausen, T.

Mol Biol Cell (2004), Volume: 15, Issue: 8, Pages: 3631-41

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Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic
Nieland, T. J.; Feng, Y.; Brown, J. X.; Chuang, T. D.; Buckett, P. D.; Wang, J.; Xie, X. S.; McGraw, T. E.; Kirchhausen, T.; Wessling-Resnick, M.

Traffic (2004), Volume: 5, Issue: 7, Pages: 478-92

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The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing
Cerny, J.; Feng, Y.; Yu, A.; Miyake, K.; Borgonovo, B.; Klumperman, J.; Meldolesi, J.; McNeil, P. L.; Kirchhausen, T.

EMBO Rep (2004), Volume: 5, Issue: 9, Pages: 883-8

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HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity
Larsen, J. E.; Massol, R. H.; Nieland, T. J.; Kirchhausen, T.

Mol Biol Cell (2004), Volume: 15, Issue: 1, Pages: 323-31

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Effects of dynamin inactivation on pathways of anthrax toxin uptake
Boll, W.; Ehrlich, M.; Collier, R. J.; Kirchhausen, T.

Eur J Cell Biol (2004), Volume: 83, Issue: 6, Pages: 281-8

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Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi
Wang, Y. J.; Wang, J.; Sun, H. Q.; Martinez, M.; Sun, Y. X.; Macia, E.; Kirchhausen, T.; Albanesi, J. P.; Roth, M. G.; Yin, H. L.

Cell (2003), Volume: 114, Issue: 3, Pages: 299-310

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T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner
Boes, M.; Bertho, N.; Cerny, J.; Op den Brouw, M.; Kirchhausen, T.; Ploegh, H.

J Immunol (2003), Volume: 171, Issue: 8, Pages: 4081-8

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Phenotypic screening of small molecule libraries by high throughput cell imaging
Yarrow, J. C.; Feng, Y.; Perlman, Z. E.; Kirchhausen, T.; Mitchison, T. J.

Come Chem High (2003), Volume: 6, Issue: 4, Pages: 279-86

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Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission
Legesse-Miller, A.; Massol, R. H.; Kirchhausen, T.

Mol Biol Cell (2003), Volume: 14, Issue: 5, Pages: 1953-63

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The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell
Chandran, K.; Parker, J. S.; Ehrlich, M.; Kirchhausen, T.; Nibert, M. L.

(2003), Volume: 77, Issue: 24, Pages: 13361-75

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Exo1: a new chemical inhibitor of the exocytic pathway
Feng, Y.; Yu, S.; Lasell, T. K.; Jadhav, A. P.; Macia, E.; Chardin, P.; Melancon, P.; Roth, M.; Mitchison, T.; Kirchhausen, T.

Proc Natl Acad Sci (2003), Volume: 100, Issue: 11, Pages: 6469-74

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Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI
Nieland, T. J.; Penman, M.; Dori, L.; Krieger, M.; Kirchhausen, T.

Proc Natl Acad Sci (2002), Volume: 99, Issue: 24, Pages: 15422-7

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The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppO sorting signals at distinct sites
Boll, W.; Rapoport, I.; Brunner, C.; Modis, Y.; Prehn, S.; Kirchhausen, T.

Traffic (2002), Volume: 3, Issue: 8, Pages: 590-600

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Clathrin adaptors really adapt
Kirchhausen, T.

Cell (2002), Volume: 109, Issue: 4, Pages: 413-6

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Single-handed recognition of a sorting traffic motif by the GGA proteins
Kirchhausen, T.

Nat Struct Biol (2002), Volume: 9, Issue: 4, Pages: 241-4

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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
Boes, M.; Cerny, J.; Massol, R.; Op den Brouw, M.; Kirchhausen, T.; Chen, J.; Ploegh, H. L.

Nature (2002), Volume: 418, Issue: 6901, Pages: 983-8

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L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1
Schaefer, A. W.; Kamei, Y.; Kamiguchi, H.; Wong, E. V.; Rapoport, I.; Kirchhausen, T.; Beach, C. M.; Landreth, G.; Lemmon, S. K.; Lemmon, V.

J Cell Biol (2002), Volume: 157, Issue: 7, Pages: 1223-32

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Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those o
Pelish, H. E.; Westwood, N. J.; Feng, Y.; Kirchhausen, T.; Shair, M. D.

J Am Chem (2001), Volume: 123, Issue: 27, Pages: 6740-1

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Structure of the Sec23p/24p and Sec13p/31p complexes of COPII
Lederkremer, G. Z.; Cheng, Y.; Petre, B. M.; Vogan, E.; Springer, S.; Schekman, R.; Walz, T.; Kirchhausen, T.

Proc Natl Acad Sci (2001), Volume: 98, Issue: 19, Pages: 10704-9

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Three ways to make a vesicle
Kirchhausen, T.

Nat Rev Mol Cell Biol (2000), Volume: 1, Issue: 3, Pages: 187-98

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Multivalent binding of nonnative substrate proteins by the chaperonin GroEL
Farr, G. W.; Furtak, K.; Rowland, M. B.; Ranson, N. A.; Saibil, H. R.; Kirchhausen, T.; Horwich, A. L.

Cell (2000), Volume: 100, Issue: 5, Pages: 561-73

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Clathrin
Kirchhausen, T.

Annu Rev Biochem (2000), Volume: 69, Pages: 699-727

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Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability
Chen, F.; Ma, L.; Parrini, M. C.; Mao, X.; Lopez, M.; Wu, C.; Marks, P. W.; Davidson, L.; Kwiatkowski, D. J.; Kirchhausen, T.; Orkin, S. H.; Rosen, F. S.; Mayer, B. J.; Kirschner, M. W.; Alt, F. W.

Curr Biol (2000), Volume: 10, Issue: 13, Pages: 758-65

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Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin
ter Haar, E.; Harrison, S. C.; Kirchhausen, T.

Proc Natl Acad Sci (2000), Volume: 97, Issue: 3, Pages: 1096-100

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Cell biology. Boa constrictor or rattlesnake?
Kirchhausen, T.

Nature (1999), Volume: 398, Issue: 6727, Pages: 470-1

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
Rohatgi, R.; Ma, L.; Miki, H.; Lopez, M.; Kirchhausen, T.; Takenawa, T.; Kirschner, M. W.

Cell (1999), Volume: 97, Issue: 2, Pages: 221-31

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Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography
Musacchio, A.; Smith, C. J.; Roseman, A. M.; Harrison, S. C.; Kirchhausen, T.; Pearse, B. M.

Mol Cell (1999), Volume: 3, Issue: 6, Pages: 761-70

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Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes
Schneider, H.; Martin, M.; Agarraberes, F. A.; Yin, L.; Rapoport, I.; Kirchhausen, T.; Rudd, C. E.

J Immunol (1999), Volume: 163, Issue: 4, Pages: 1868-79

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Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF
Jones, A. T.; Spiro, D. J.; Kirchhausen, T.; Melancon, P.; Wessling-Resnick, M.

J Cell Sci (1999), Volume: 112 ( Pt 20), Pages: 3477-85

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Adaptors for clathrin-mediated traffic
Kirchhausen, T.

Annu Rev Cell Dev Biol (1999), Volume: 15, Pages: 705-32

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Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors
Cupers, P.; Jadhav, A. P.; Kirchhausen, T.

J Biol Chem (1998), Volume: 273, Issue: 4, Pages: 1847-50

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The clathrin endocytic pathway in viral infection
DeTulleo, L.; Kirchhausen, T.

EMBO J (1998), Volume: 17, Issue: 16, Pages: 4585-93

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Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker
ter Haar, E.; Musacchio, A.; Harrison, S. C.; Kirchhausen, T.

Cell (1998), Volume: 95, Issue: 4, Pages: 563-73

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The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway
Kamiguchi, H.; Long, K. E.; Pendergast, M.; Schaefer, A. W.; Rapoport, I.; Kirchhausen, T.; Lemmon, V.

J Neuroscience (1998), Volume: 18, Issue: 14, Pages: 5311-21

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Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation
Kirchhausen, T.

Molecular medicine today (1998), Volume: 4, Issue: 7, Pages: 300-4

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Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-ba
Rapoport, I.; Chen, Y. C.; Cupers, P.; Shoelson, S. E.; Kirchhausen, T.

EMBO J (1998), Volume: 17, Issue: 8, Pages: 2148-55

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Vesicle formation: dynamic dynamin lives up to its name
Kirchhausen, T.

Curr Biol (1998), Volume: 8, Issue: 22, Pages: R792-4

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Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1
Tong, X.; Boll, W.; Kirchhausen, T.; Howley, P. M.

J Virol (1998), Volume: 72, Issue: 1, Pages: 476-82

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A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
Greenberg, M.; DeTulleo, L.; Rapoport, I.; Skowronski, J.; Kirchhausen, T.

Curr Biol (1998), Volume: 8, Issue: 22, Pages: 1239-42

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A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots
Sanderfoot, A. A.; Ahmed, S. U.; Marty-Mazars, D.; Rapoport, I.; Kirchhausen, T.; Marty, F.; Raikhel, N. V.

Proc Natl Acad Sci (1998), Volume: 95, Issue: 17, Pages: 9920-5

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Membranes and sorting. Membrane permeability
Kirchhausen, T.; Pines, J.; Toldo, L.; Lafont, F.

Curr Opin Cell Biol (1997), Volume: 9, Issue: 4, Pages: 473

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A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated ves
Clairmont, K. B.; Boll, W.; Ericsson, M.; Kirchhausen, T.

Cell Mol Life Sci (1997), Volume: 53, Issue: 7, Pages: 611-9

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Linking cargo to vesicle formation: receptor tail interactions with coat proteins
Kirchhausen, T.; Bonifacino, J. S.; Riezman, H.

Curr Opin Cell Biol (1997), Volume: 9, Issue: 4, Pages: 488-95

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Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15
Cupers, P.; ter Haar, E.; Boll, W.; Kirchhausen, T.

J Biol Chem (1997), Volume: 272, Issue: 52, Pages: 33430-4

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Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
Rapoport, I.; Miyazaki, M.; Boll, W.; Duckworth, B.; Cantley, L. C.; Shoelson, S.; Kirchhausen, T.

EMBO J (1997), Volume: 16, Issue: 9, Pages: 2240-50

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Identification of Itk/Tsk Src homology 3 domain ligands
Bunnell, S. C.; Henry, P. A.; Kolluri, R.; Kirchhausen, T.; Rickles, R. J.; Berg, L. J.

J Biol Chem (1996), Volume: 271, Issue: 41, Pages: 25646-56

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Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
Boll, W.; Ohno, H.; Songyang, Z.; Rapoport, I.; Cantley, L. C.; Bonifacino, J. S.; Kirchhausen, T.

EMBO J (1996), Volume: 15, Issue: 21, Pages: 5789-95

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Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro
Spiro, D. J.; Boll, W.; Kirchhausen, T.; Wessling-Resnick, M.

Mol Biol Cell (1996), Volume: 7, Issue: 3, Pages: 355-67

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Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42
Kolluri, R.; Tolias, K. F.; Carpenter, C. L.; Rosen, F. S.; Kirchhausen, T.

Proc Natl Acad Sci (1996), Volume: 93, Issue: 11, Pages: 5615-8

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Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways
Bonifacino, J. S.; Marks, M. S.; Ohno, H.; Kirchhausen, T.

(1996), Volume: 108, Issue: 4, Pages: 285-95

Disease mechanism: unravelling Wiskott-Aldrich syndrome
Kirchhausen, T.; Rosen, F. S.

(1996), Volume: 6, Issue: 6, Pages: 676-8

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Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits
Tebar, F.; Sorkina, T.; Sorkin, A.; Ericsson, M.; Kirchhausen, T.

J Biol Chem (1996), Volume: 271, Issue: 46, Pages: 28727-30

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A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-rel
Stepp, J. D.; Pellicena-Palle, A.; Hamilton, S.; Kirchhausen, T.; Lemmon, S. K.

Mol Biol Cell (1995), Volume: 6, Issue: 1, Pages: 41-58

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Interaction of tyrosine-based sorting signals with clathrin-associated proteins
Ohno, H.; Stewart, J.; Fournier, M. C.; Bosshart, H.; Rhee, I.; Miyatake, S.; Saito, T.; Gallusser, A.; Kirchhausen, T.; Bonifacino, J. S.

Science (1995), Volume: 269, Issue: 5232, Pages: 1872-5

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Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells
Speelman, B. A.; Allen, K.; Grounds, T. L.; Neutra, M. R.; Kirchhausen, T.; Wilson, J. M.

J Biol Chem (1995), Volume: 270, Issue: 4, Pages: 1583-8

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Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2
Sorkin, A.; McKinsey, T.; Shih, W.; Kirchhausen, T.; Carpenter, G.

J Biol Chem (1995), Volume: 270, Issue: 2, Pages: 619-25

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Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2
Boll, W.; Gallusser, A.; Kirchhausen, T.

Curr Biol (1995), Volume: 5, Issue: 10, Pages: 1168-78

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A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes
Shih, W.; Gallusser, A.; Kirchhausen, T.

J Biol Chem (1995), Volume: 270, Issue: 52, Pages: 31083-90

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Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi
Rad, M. R.; Phan, H. L.; Kirchrath, L.; Tan, P. K.; Kirchhausen, T.; Hollenberg, C. P.; Payne, G. S.

J Cell Sci (1995), Volume: 108 ( Pt 4), Pages: 1605-15

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The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence f
Phan, H. L.; Finlay, J. A.; Chu, D. S.; Tan, P. K.; Kirchhausen, T.; Payne, G. S.

EMBO J (1994), Volume: 13, Issue: 7, Pages: 1706-17

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Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-recepto
Osborn, L.; Vassallo, C.; Browning, B. G.; Tizard, R.; Haskard, D. O.; Benjamin, C. D.; Dougas, I.; Kirchhausen, T.

J Cell Biol (1994), Volume: 124, Issue: 4, Pages: 601-8

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A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles
Sogaard, M.; Tani, K.; Ye, R. R.; Geromanos, S.; Tempst, P.; Kirchhausen, T.; Rothman, J. E.; Sollner, T.

Cell (1994), Volume: 78, Issue: 6, Pages: 937-48

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Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy
Kirchhausen, T.; Staunton, D. E.; Springer, T. A.

J Leukoc Biol (1993), Volume: 53, Issue: 3, Pages: 342-6

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Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers
Kirchhausen, T.; Toyoda, T.

J Biol Chem (1993), Volume: 268, Issue: 14, Pages: 10268-73

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The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components
Gallusser, A.; Kirchhausen, T.

EMBO J (1993), Volume: 12, Issue: 13, Pages: 5237-44

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The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast
Nakayama, Y.; Goebl, M.; O'Brine Greco, B.; Lemmon, S.; Pingchang Chow, E.; Kirchhausen, T.

Eur J Biochem (1991), Volume: 202, Issue: 2, Pages: 569-74

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AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative h
Kirchhausen, T.; Davis, A. C.; Frucht, S.; Greco, B. O.; Payne, G. S.; Tubb, B.

J Biol Chem (1991), Volume: 266, Issue: 17, Pages: 11153-7

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Clathrin domains involved in recognition by assembly protein AP-2
Keen, J. H.; Beck, K. A.; Kirchhausen, T.; Jarrett, T.

J Biol Chem (1991), Volume: 266, Issue: 12, Pages: 7950-6

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Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3
Scarmato, P.; Kirchhausen, T.

J Biol Chem (1990), Volume: 265, Issue: 7, Pages: 3661-8

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Sequence of the rat alpha c large chain of the clathrin associated protein complex AP-2
Tucker, K. L.; Nathanson, K.; Kirchhausen, T.

Nucleic Acids Res (1990), Volume: 18, Issue: 17, Pages: 5306

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Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes
Kirchhausen, T.

Mol Cell Biol (1990), Volume: 10, Issue: 11, Pages: 6089-90

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Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2
Matsui, W.; Kirchhausen, T.

Biochemistry (1990), Volume: 29, Issue: 48, Pages: 10791-8

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Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein com
Kirchhausen, T.; Nathanson, K. L.; Matsui, W.; Vaisberg, A.; Chow, E. P.; Burne, C.; Keen, J. H.; Davis, A. E.

Proc Natl Acad Sci (1989), Volume: 86, Issue: 8, Pages: 2612-6

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Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles
Thurieau, C.; Brosius, J.; Burne, C.; Jolles, P.; Keen, J. H.; Mattaliano, R. J.; Chow, E. P.; Ramachandran, K. L.; Kirchhausen, T.

DNA (1988), Volume: 7, Issue: 10, Pages: 663-9

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Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs
Kirchhausen, T.; Scarmato, P.; Harrison, S. C.; Monroe, J. J.; Chow, E. P.; Mattaliano, R. J.; Ramachandran, K. L.; Smart, J. E.; Ahn, A. H.; Brosius, J.

Science (1987), Volume: 236, Issue: 4799, Pages: 320-4

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Clathrin heavy chain: molecular cloning and complete primary structure
Kirchhausen, T.; Harrison, S. C.; Chow, E. P.; Mattaliano, R. J.; Ramachandran, K. L.; Smart, J.; Brosius, J.

Proc Natl Acad Sci (1987), Volume: 84, Issue: 24, Pages: 8805-9

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Configuration of clathrin trimers: evidence from electron microscopy
Kirchhausen, T.; Harrison, S. C.; Heuser, J.

J Ultrastruct Mol (1986), Volume: 94, Issue: 3, Pages: 199-208

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DNA gyrase and its complexes with DNA: direct observation by electron microscopy
Kirchhausen, T.; Wang, J. C.; Harrison, S. C.

Cell (1985), Volume: 41, Issue: 3, Pages: 933-43

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Deep-etch views of clathrin assemblies
Heuser, J.; Kirchhausen, T.

Journal of Ultrastructure Research (1985), Volume: 92, Issue: 1-2, Pages: 1-27

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Structural domains of clathrin heavy chains
Kirchhausen, T.; Harrison, S. C.

J Cell Biol (1984), Volume: 99, Issue: 5, Pages: 1725-34

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Clathrin, cages, and coated vesicles
Harrison, S. C.; Kirchhausen, T.

Cell (1983), Volume: 33, Issue: 3, Pages: 650-2

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Location and distribution of the light chains in clathrin trimers
Kirchhausen, T.; Harrison, S. C.; Parham, P.; Brodsky, F. M.

Proc Natl Acad Sci (1983), Volume: 80, Issue: 9, Pages: 2481-5

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Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution
Hogle, J.; Kirchhausen, T.; Harrison, S. C.

J Mol Biol (1983), Volume: 171, Issue: 1, Pages: 95-100

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Thermal effects in human plasma high density lipoproteins (HDL)3: a 13C-FT-NMR study
Leon, V.; Kirchhausen, T.; Avila, E. M.; Mateu, L.

Acta Cient (1983), Volume: 34, Issue: 3-4, Pages: 209-15

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Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells
Fless, G. M.; Kirchhausen, T.; Fischer-Dzoga, K.; Wissler, R. W.; Scanu, A. M.

Atherosclerosis (1982), Volume: 41, Issue: 2-3, Pages: 171-83

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Protein organization in clathrin trimers
Kirchhausen, T.; Harrison, S. C.

Cell (1981), Volume: 23, Issue: 3, Pages: 755-61

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The structure of plasma low density lipoproteins: experimental facts and interpretations--a minireview
Kirchhausen, T.; Fless, G.; Scanu, A. M.

Lipids (1980), Volume: 15, Issue: 6, Pages: 464-7

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Atherogenic diets and neutral-lipid organization in plasma low density lipoproteins
Kirchhausen, T.; Untracht, S. H.; Fless, G. M.; Scanu, A. M.

(1979), Volume: 33, Issue: 1, Pages: 59-70

Kinetics of thermal transitions in human serum low density lipoproteins (LDL) and neutral lipids. A dynamic small-angle X-ray sc
Mateu, L.; Kirchhausen, T.

Acta Cient (1979), Volume: 30, Issue: 5, Pages: 478-83

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Small-angle X-ray scattering and differential scanning calorimetry studies on reversibly modified human-serum low density lipopr
Mateu, L.; Kirchhausen, T.; Camejo, G.

Biochemistry (1978), Volume: 17, Issue: 8, Pages: 1436-40

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Small-angle x-ray scattering study of human serum low-density lipoproteins with differential reactivity for an arterial proteogl
Mateu, L.; Kirchhausen, T.; Padron, R.; Camejo, G.

J Supramol Struct (1977), Volume: 7, Issue: 3-4, Pages: 435-42

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A low temperature structural transition in human serum low density lipoproteins
Mateu, L.; Kirchhausen, T.; Camejo, G.

Biochim Biophys Acta (1977), Volume: 487, Issue: 1, Pages: 243-5

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